Hoodia P57. Enough to put you off your food - Part II


                 
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P57. Enough to put you off your food
- Part II

Alok Jha
Saturday December 3, 2009
The Guardian

Phytopharm initially worked with Pfizer on bringing hoodia to market. In 2002, a trial on 30 obese adults showed that the intake of people given the p57 extract dropped by 1,000 calories a day. But after spending around $25m (£14.4m) Pfizer dropped their work on the plant. Pfizerwanted to put p57 into a pill, but the extract was too complex to make artificially. In late 2004, Unilever stepped in, and in a £21m deal, said that it intended to commercially grow hoodia, an endangered plant in its native South Africa, and use the extract in its slimming foods.

"Any product we develop will be a food product or a food additive rather than a pill," said Trevor Gorin of Unilever. Though Unilever and Phytopharm say that a hoodia product is some years away, a black market trade has already sprung up.

Scientists at Unilever say they have carried out tests on food supplements available on the internet and that people are being duped.

"All these supplements appear to have nearly no plant extract in them and are fraudulent in one way or another," said Mr Gorin.

"If a supplement was using hoodia gordonii, we would be pursuing them for encroaching on our intellectual property rights."

While p57 holds plenty of promise to help people regulate weight without having to resort to pharmaceuticals, Prof Blundell said that, as more of the mysteries of appetite regulation are cracked, more targets for treatments will become apparent.

Recently a new hormone was discovered that seems to suppress appetite - obestatin. "It's clear that there are many molecules floating around in our bodies doing things with some functional properties that we haven't yet discovered," said Prof Blundell.

For scientists trying to work out how to curb the obesity problem, a product that can be simply added to food may have immense value.

"There's every prospect of finding an appetite-controlling molecule in this or other plants - and I'm pretty excited by that," said Prof Blundell.




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